Journal article
Extent of disease on high-resolution computed tomography lung is a predictor of decline and mortality in systemic sclerosis-related interstitial lung disease
OA Moore, N Goh, T Corte, H Rouse, O Hennessy, V Thakkar, J Byron, J Sahhar, J Roddy, E Gabbay, P Youssef, P Nash, J Zochling, SM Proudman, W Stevens, M Nikpour
Rheumatology United Kingdom | Published : 2013
Abstract
disease on high-resolution CT (HRCT) lung, reported using a simple grading system, is predictive of decline and mortality in SSc-related interstitial lung disease (SSc-ILD), independently of pulmonary function tests (PFTs) and other prognostic variables.Methods. SSc patients with a baseline HRCT performed at the time of ILD diagnosis were identified. All HRCTs and PFTs performed during follow-up were retrieved. Demographic and disease-related data were prospectively collected. HRCTs were graded according to the percentage of lung disease: >20%: extensive; 20%) on HRCT at baseline, reported using a semi-quantitative grading system, is associated with a three-fold increased risk of deteriorati..
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Funding Acknowledgements
This work was supported by a University of Melbourne Early Career Research Grant (M.N. and O.A.M.); Scleroderma Australia; Arthritis Australia; Actelion Australia; Bayer; CSL Biotherapies; GlaxoSmithKline Australia; and Pfizer.